First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.
نویسندگان
چکیده
Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.
منابع مشابه
Ethynylbenzenoid metabolites of Antrodia camphorata: synthesis and inhibition of TNF expression.
An improved synthesis of the anti-inflammatory natural product antrocamphin A (2), involving a key Castro-Stephens reaction, is presented, along with the first total synthesis of its congener antrocamphin B (3). Approaches towards the more complex co-metabolite antrodioxolanone (4) were unsuccessful, but a samarium diiodide-mediated pinacol coupling of antrocamphin B did provide the chiral epim...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 1 شماره
صفحات -
تاریخ انتشار 2011